The role of plasma kallikrein in HAE

Discover the critical role that uncontrolled plasma kallikrein (PK) plays in acute attacks of hereditary angioedema (HAE). In this video, find out how C1 inhibitor deficiency is characterised by recurrent, unpredictable HAE episodes caused by uncontrolled PK generation, which results from cleavage of high-molecular-weight kininogen (CHMWK).